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University of Hawaii Cancer Center

News Highlights

February 21, 2018

The future of cancer prevention and patient care

HONOLULU

The University of Hawai'i Cancer Center through its various activities, cancer trial patients and their guests, and other visitors adds more than $54 million to the O'ahu economy. It is one of only 69 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai'i at Mānoa, the Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawai'i and the Pacific.
Learn more at www.uhcancercenter.org. Like us on Facebook at www.facebook.com/UHCancerCenter. Follow us on Twitter @UHCancerCenter.

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News Highlights

April 10, 2018

3D SCANNERS GIVE NEW INSIGHT TO BODY SHAPE AND HEALTH

HONOLULU – The University of Hawai‘i Cancer Center is studying how body shape information can improve health by using 3D optical scanners and advanced statistical modeling.

“Human body shape is an intuitive marker of health. Emerging 3D optical scanners are safe, inexpensive and accessible. We envision that monitoring body shape when exercising, or changing your diet gives you more useful feedback than change in weight on a scale, and will help people be more successful with their lifestyle changes, live healthier and live longer,” said John Shepherd, PhD, principal investigator of the study and epidemiology researcher at the UH Cancer Center.

Shepherd, his team and collaborators lead the Shape Up! Study funded by the National Institutes of Health (NIH). The study aims to develop tools and techniques to derive clinical health information from 3D body scanners.

Researchers will take full-body optical 3D scans at high spatial resolution of 720 adults and 720 kids. The participants will have other measures that are related to health and well-being including,

  • dual-energy X-ray absorptiometry (DXA) scans for body composition,
  • blood test for metabolic markers,
  • strength assessments, and
  • questions regarding their lifestyle and eating habits.

“With this data, we can do some amazing things including modeling body shape changes due to loss or gain of muscle and fat. The findings from these studies will empower researchers, clinicians, and even consumers to measure and monitor their body shape and health,” said Shepherd.

Body shape scans create avatars of the person. Researchers have found there is more impact on a person when her or she looks at a 3D image of themselves versus knowing their weight. The modeling shows where weight came off, or where it could come off with further exercise/nutritional changes. It also shows detailed information of where the waist gets smaller, or where the thighs get smaller.

3D OPTICAL BODY SCAN EXAMPLE

The middle image below is how Shepherd, of the Shape Up Study, looks with his Body Mass Index (BMI) value. What if he lost or gained pure fat? The image on the left is 44 pounds less fat than the current Shepherd in the middle. The far right image is if Shepherd gained 44 pounds of fat. The three images have the same underlying muscle.

3D-body-scan

Shepherd’s research team also looks to develop home body scan devices that accurately predict percent body fat from body shape. The device would show individuals how their body will change when they lose fat and/or gain muscle.

Having an optical body shape system at home could be beneficial for people who have limited access advanced optical imagers and other more expensive technologies.

The Shape Up! Cohort Study is funded by the National Institutes of Health, and is a partnership with the University of Washington Computer Science Department, Pennington Biomedical Research Center, and the University of California at San Francisco.

Interested in participating in the study? Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. or call 808-440-5234


More at: http://www.kitv.com/clip/14272063/3d-body-scanning-turns-users-into-avatars


The University of Hawai'i Cancer Center through its various activities, cancer trial patients and their guests, and other visitors adds more than $54 million to the O'ahu economy. It is one of only 69 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai'i at Mānoa, the Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawai'i and the Pacific.
Learn more at www.uhcancercenter.org. Like us on Facebook at www.facebook.com/UHCancerCenter. Follow us on Twitter @UHCancerCenter.

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News Highlights

May 15, 2018

UH Cancer Center scientists recognized for international mesothelioma research impact

University of Hawai‘i Cancer Center researchers were awarded for outstanding mesothelioma research from The International Mesothelioma Interest Group (iMig). The researchers were awarded both of the two awards chosen every two years by iMig.

iMig Wagner Medal 2018: Michele CarboneMichele Carbone, MD, PhD

Michele Carbone, MD, PhD, for "discovering the role and mechanisms of genetics in the pathogenesis of mesothelioma".

iMig presents the Wagner Medal every two years to an individual who has made major original contributions to the understanding of mesothelioma, either in basic or applied research. The Wagner Medal is the highest honor presented by the International Mesothelioma Interest Group to a leader in the field.


Haining Yang, PhD


iMig Research Award 2018: Haining Yang
Haining Yang, MD, PhD, for "discovering the mechanisms of asbestos carcinogenesis".

The iMig Research Award is awarded every two years to recognize the potential significance and impact on the field of novel mesothelioma research (basic, translational, or clinical).

Drs. Carbone and Yang share a lab at the UH Cancer Center and together lead an international team of fellows and students.


iMig is an independent international group of scientists and clinicians working to understand, cure and prevent mesothelioma.


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The University of Hawai'i Cancer Center through its various activities, cancer trial patients and their guests, and other visitors adds more than $54 million to the O'ahu economy. It is one of only 69 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai'i at Mānoa, the Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawai'i and the Pacific.
Learn more at www.uhcancercenter.org. Like us on Facebook at www.facebook.com/UHCancerCenter. Follow us on Twitter @UHCancerCenter.


News Highlights

May 22, 2018

Graduate student wins multiple awards for sepsis research

Natalija Glibetic, a Molecular Biosciences and Bioengineering graduate student has won multiple awards for sepsis research conducted at the University of Hawai‘i Cancer Center in Michelle L. Matter’s lab of the Cancer Biology Program.

“I am incredibly grateful for all the support and attention my work has received. Sepsis is the leading cause of death in U.S. hospitals and accounts for 8.5 percent of cancer patient deaths each year, yet there are no sepsis-specific therapies. Native Hawaiians are particularly susceptible to cancer-associated sepsis, so it is crucial to develop these therapies for Hawai‘I,” said Glibetic. “Presenting at these symposiums, I was hoping that I could bring more attention to sepsis and the exciting work we are doing in Michelle L. Matter's lab at the UH Cancer Center. Hopefully, with my contribution we will be a step closer to stopping sepsis.”

  • 1st Place Best Poster - Graduate Division
    2018 JABSOM Biomedical & Health Disparities Symposium
    Poster: R-Ras: a key regulator of sepsis-mediated vascular permeability.
  • 30-year Anniversary Overall Best Master’s Poster
    2018 CTAHR's Student Research Symposium
    Poster: R-Ras: a key regulator of sepsis-mediated vascular permeability.
  • 1st Place Master’s 3-Minute Elevator Pitch
    2018 CTAHR’s 3-Minute Elevator Pitch Competition
    Going with the flow to stop sepsis
  • Runner-up 3 Minute Thesis Award
    2018 Graduate Division 3-Minute Thesis (3MT) Competition
    Going with the flow to stop sepsis

Natalia Glibetic at the Graduate Division 3-Minute Thesis Competition
Natalia Glibetic at the Graduate Division 3-Minute Thesis Competition

Natalia Glibetic at the Graduate Division 3-Minute Thesis Competition
From left, Michelle L. Matter and Natalija Glibetic at the Master's 3-minute Elevator Pitch Competition


Research: Stopping sepsis-mediated blood vessel leakage
Glibetic’s research focuses on the regulation of vascular leakage in sepsis and cancer-associated sepsis. Glibetic found a protein that is crucial in maintaining blood vessel integrity that blocks sepsis-induced vascular leakage. The protein acts as a key switch from an unhealthy leaky vessel to a healthy blood vessel.

Blood vessels are lined by endothelial cells that act as gatekeepers for the movement of fluids and nutrients from the bloodstream into the underlying tissue. In sepsis these cells dysfunction leading to increased vascular leakage that can induce tissue swelling, multiple organ failure and death.

People with cancer are particularly susceptible to developing sepsis due to suppression of the immune system that can occur from the cancer itself or from surgery, chemotherapy or radiation therapy used to treat the disease. 8.5 percent of cancer patients die from cancer-associated sepsis each year, with Native Hawaiians being particularly susceptible. Currently there are no treatments for sepsis, and all therapies are supportive.

“We are now focused on moving our work into pre-clinical models as the protein is an exciting target for developing sepsis-specific therapies, and could lead to the development of treatments for other diseases such as atherosclerosis and diabetes,” said Glibetic.


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The University of Hawai'i Cancer Center through its various activities, cancer trial patients and their guests, and other visitors adds more than $54 million to the O'ahu economy. It is one of only 69 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai'i at Mānoa, the Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawai'i and the Pacific.
Learn more at www.uhcancercenter.org. Like us on Facebook at www.facebook.com/UHCancerCenter. Follow us on Twitter @UHCancerCenter.