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Wei Jia, PhD

Wei Jia, PhD

Wie Jia, PhD
  • Associate Director for Shared Resources
  • Faculty Director
    Metabolomics Shared Resource
  • Full Member
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Academic Appointments

  • Professor (Researcher)
    Cancer Biology Program
    University of Hawaii Cancer Center

Degrees

  • M.Sc. in Radiopharmaceutical Chemistry, University of Missouri –
    Columbia
  • Ph.D. in Radiopharmaceutical Chemistry, University of Missouri –
    Columbia

Honors

  • 2003 - 2008, Outstanding Faculty Award, School of Pharmacy, Shanghai Jiao Tong University, China
  • 2004, New Century Talents Award, Ministry of Education, China
  • 2005, The Aurora Scholar Award, Shanghai, China
  • 2007, The Shanghai Leading Scientist Award, 2007
  • 2017, Founding Member of the Metabolomics Association of North America

Research Focus

Dr. Jia joined the University of Hawaii Cancer Center in 2013 as the Associate Director for Shared Resources. Previously, he spent about five years as a Professor at University of North Carolina at Greensboro and Co-Director of UNCG Center for Translational Biomedical Research. Prior to his appointment with UNCG, Dr. Jia worked in China for 10 years, as Professor and Executive Vice Dean at College of Pharmaceutical Science, Tianjin University, and Professor and Vice Dean for Research, School of Pharmacy, Shanghai Jiao Tong University.

Dr. Jia's research interest involves carbon source metabolism and its regulation in cancer cells as well as the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to metabolic disorders and gastrointestinal cancer. Several research projects are being conducted in Dr. Jia's group to decipher the complex metabolic interactions in gut-liver-brain axis and regulation of cancer cell metabolism.

In addition, Dr. Jia directs a well-recognized metabolomics laboratory (currently as one of the UH Cancer Center shared resources). Over the past 13 years, his lab has developed a number of metabolomics technologies and protocols, focusing on the quantitative analysis of endogenous small-molecule metabolites and trace elements from biological specimens including blood, urine, saliva, and tissues of experimental animals and human subjects. Many of these technologies have been applied in clinical and translational research, involving (1) unbiased metabolic profiling and data mining, metabolite annotation and biological interpretation using combined high sensitivity, high throughput LC-MS-MS and GC-MS platforms; (2) targeted and quantitative analysis of metabolic rates and pathways using isotope labeled common substrates such as glucose and cholate; (3) classification and prediction of disease phenotypes based on their unique metabolic signatures and biomarkers for patient stratification and personalized treatment; and (4) novel methodologies to delineate the host-gut microbe co-metabolism of diets and multi-component herbal medicines, such as poly-pharmacokinetics and gut microbial metabolomics.

Selected Publications

  • Jia W, Xie GX, Jia, WP. (2018). Bile acids and microbiome cross-talk and its impact on gastrointestinal carcinogenesis. Nature Reviews Gastroenterology and Hepatology. 15(2):111-128.
  • Xie, G.X., Wang, X.N., Jiang, R.Q., Zhao, A.H., Yan, J.Y., Zheng, X.J., Huang, F.J., Liu, X.Z., Panee, J., Rajani, C., Yao, C., Yu, H., Jia, W.P., Sun, B.C., Liu, P., Jia, W. (2018). Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure. EBioMedicine. 37:294-306.
  • Chen WL, Wang YY, Zhao AH, Xia L, Xie GX, Su MM, Zhao LJ, Liu JJ, Qu C, Wei RM, Rajani C, Ni Y, Cheng Z, Chen Z, Chen SJ, Jia, W. (2016). Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential, Cancer Cell. 30(5), 779-791. PMID: 27746145.
  • Xie, GX, Wang, XN, Huang, FJ, Zhao, AH, Chen, WL, Yan, JY, Zhang, YJ, Lei, S, Ge, K, Zheng, XJ, Liu, JJ, Su, MM, Liu, P, Jia, W. (2016). Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. International Journal of Cancer. 139(8), 1764-1775. PMID: 27273788.
  • Qiu YP, Cai GX, Zhou BS, Li D, Zhao AH, Xie GX, Li HK, Cai SJ, Xie D, Huang CZ, Ge WT, Zhou ZX, Xu L, Jia WP, Zheng S, Yen Y, Jia W. (2014). A distinct metabolic signature of human colorectal cancer with prognostic potential. Clinical Cancer Research. 20(8), 2136-2146. PMID: 24526730.

Publication list via PubMed

Active Grants

  • W. Jia, Co-Investigator, J. Turkson, PI
    R01 CA208851, NIH, NCI
    “STAT3, G6PD and TrxR as underlying mechanisms for antitumor responses to hirsutinolides”
    The goal of this project is to develop new hirsutinolide analogs and assess their inhibitory activities against STAT3, G6PD and TrxR1 and their mechanisms for inhibiting human breast and flioma tumors.
    03/02/17 – 02/28/22
  • W. Jia, Co-Investigator, R. Holcombe, PI
    P30 CA071789, University of Hawaii CCSG, NCI
    The major goal of this project is to continue to lower cancer incidence and improve the care of cancer patients in Hawaii and elsewhere by attempting to understand reasons for the remarkable ethnic-related cancer associations found in the region.
    07/01/97 – 06/30/21
  • W. Jia, Principal Investigator
    1U01 CA188387, NIH, NCI
    "Gut microbiota mediated bile acid alterations in hepatic carcinogenesis"
    Alterations in gut bacteria may result in an increase in the concentration of toxic bile acids in liver, causing sustained liver injury and the subsequent development of liver fibrosis and cancer. The proposed study will help us design novel therapeutic approaches to protect against the development of liver cancer.
    08/01/15 - 07/31/20
  • W. Jia, Principal Investigator
    Nestle Institute of Health Sciences Ltd.
    "Characterizing the metabolic footprints of gut microbial host co-metaboism"
    Exploratory study to characterize the metabolic footprints of gut microbial host co-metabolism in m human infants with cow milk protein allergy.
    08/01/18 - 07/31/20
  • W. Jia, Co-Investigator, UNC-Chapel Hill subcontract, Brouwer, Principal Investigator
    R01 GM041935, NIH/NIGMS
    "Altered Hepatic Disposition of Anionic Drugs-Mechanisms"
    This project will study the mechanisms of the durg-induced liver conditions with important pathophysiological consequences such as liver cancer. My laboratory will quantitatively analyze the bile acids in biological samples generated from this project over the 5-year period.
    09/01/14 - 8/31/19