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Seminar Series

2018 Seminar Speakers

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2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012

Keshav Singh, PhD
University of Alabama at Birmingham

Date/Time: April 19, 2018 / 12:00 PM
Title: Numtogenesis as a Mechanism for Development of Cancer
Venue: MEB Multipurpose Room #301, John A. Burns School of Medicine

20BY25 One Step Closer

What is 20BY25?

Overall Goal – Ensure that the people of Hawai‘i receive the highest quality of cancer care

Clinical Trials Facts

  1. Clinical trials provide the highest level of quality of care for patients with cancer1
  2. The mortality rate from cancer is falling, in large part due to cancer research that has, through clinical trials, led to new and better methods of cancer prevention, detection and treatment.
  3. Children with cancer are enrolled onto clinical trials at a rate of 70-75% across the US.  A clinical trial is the standard of care.
  4. Only 2-3% of adults with cancer in the US enroll onto clinical trials.

Why do clinical trials provide the highest quality of care for cancer patients?

  1. Closer supervision and monitoring than standard care
  2. Patients always receive equal to or better than the standard of care
  3. Access to novel drugs, or new drug combinations, that may improve the response to treatment, increase the chance of cure, and prolong survival

Today’s “standard” treatment was a
clinical trial 5-10 years ago

Today’s clinical trial will be
standard care 5-10 years from now

Initiative focused on:

    • Community education about cancer clinical trials
    • Engagement and training of oncology providers
    • Encouraging enrollment to cancer clinical trials

Long Term Goal

20% of all Hawaii cancer cases each year enrolled to cancer clinical trials by 2025.

    • There are ~6500 new cancer cases each year in Hawaii
    • The goal is to enroll 1300 patients per year onto a cancer clinical trial
    • At least 1/2 of these enrollments should be to treatment-based trials.  Others may be to cancer prevention, supportive care, diagnostic and cancer healthcare delivery trials.

Hawaii will be the ONLY state in the US to achieve this high proportion of enrollment to clinical trials statewide.

The University of Hawaii Cancer Center, which already provides a clinical trial infrastructure for over 2/3 of cancer patients in the State, is uniquely positioned to lead this initiative.

Key Activities of the Initiative:

  • Educate the public about the value of cancer clinical trials
  • Establish a training and certification program for providers (physicians, nurses), clinical research staff and lay advocates/educators
  • Augment the clinical trials infrastructure to facilitate community-based clinical trials participation and enrollment on Oahu
  • Establish partners on neighbor islands to extend access to clinical trials
  • Coordinate cancer clinical trials across various healthcare systems in Hawai‘i




Corporate, Healthcare and Foundation Sponsorships

Individual Sponsorships

1National Comprehensive Cancer Network; American Cancer Society; National Cancer Institute


This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

To support 20BY25, please contact:

Todd Cullison

Associate Director of Development,
UH Cancer Center

701 Ilalo Street, 3rd Floor
Honolulu, HI 96813
(808) 356-5757
(808) 586-3052

This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

More Information:

American Cancer Society Clinical Trials

National Cancer Institute Clinical Trials

What are Clinical Trials?

Clinical Trials National Website

UH Cancer Center Clinical Trials Office

News Highlights

April 10, 2018


HONOLULU – The University of Hawai‘i Cancer Center is studying how body shape information can improve health by using 3D optical scanners and advanced statistical modeling.

“Human body shape is an intuitive marker of health. Emerging 3D optical scanners are safe, inexpensive and accessible. We envision that monitoring body shape when exercising, or changing your diet gives you more useful feedback than change in weight on a scale, and will help people be more successful with their lifestyle changes, live healthier and live longer,” said John Shepherd, PhD, principal investigator of the study and epidemiology researcher at the UH Cancer Center.

Shepherd, his team and collaborators lead the Shape Up! Study funded by the National Institutes of Health (NIH). The study aims to develop tools and techniques to derive clinical health information from 3D body scanners.

Researchers will take full-body optical 3D scans at high spatial resolution of 720 adults and 720 kids. The participants will have other measures that are related to health and well-being including,

  • dual-energy X-ray absorptiometry (DXA) scans for body composition,
  • blood test for metabolic markers,
  • strength assessments, and
  • questions regarding their lifestyle and eating habits.

“With this data, we can do some amazing things including modeling body shape changes due to loss or gain of muscle and fat. The findings from these studies will empower researchers, clinicians, and even consumers to measure and monitor their body shape and health,” said Shepherd.

Body shape scans create avatars of the person. Researchers have found there is more impact on a person when her or she looks at a 3D image of themselves versus knowing their weight. The modeling shows where weight came off, or where it could come off with further exercise/nutritional changes. It also shows detailed information of where the waist gets smaller, or where the thighs get smaller.


The middle image below is how Shepherd, of the Shape Up Study, looks with his Body Mass Index (BMI) value. What if he lost or gained pure fat? The image on the left is 44 pounds less fat than the current Shepherd in the middle. The far right image is if Shepherd gained 44 pounds of fat. The three images have the same underlying muscle.


Shepherd’s research team also looks to develop home body scan devices that accurately predict percent body fat from body shape. The device would show individuals how their body will change when they lose fat and/or gain muscle.

Having an optical body shape system at home could be beneficial for people who have limited access advanced optical imagers and other more expensive technologies.

The Shape Up! Cohort Study is funded by the National Institutes of Health, and is a partnership with the University of Washington Computer Science Department, Pennington Biomedical Research Center, and the University of California at San Francisco.

Interested in participating in the study? Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. or call 808-440-5234

More at:

The University of Hawai'i Cancer Center through its various activities, cancer trial patients and their guests, and other visitors adds more than $54 million to the O'ahu economy. It is one of only 69 research institutions designated by the National Cancer Institute. Affiliated with the University of Hawai'i at Mānoa, the Center is dedicated to eliminating cancer through research, education, patient care and community outreach with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawai'i and the Pacific.
Learn more at Like us on Facebook at Follow us on Twitter @UHCancerCenter.


Seminar Series

2017 Seminar Speakers

View by year:
2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012

Hua Zhao, PhD

  • Date: July 17, 2017
  • Title: Molecular Epidemiology of Cancer and Obesity in the Mexican American Mano A Mano Cohort"
  • UT MD Anderson Cancer Center
Melissa A. Merritt, PhD

  • Date: July 11, 2017
  • Title: Ovarian and Endometrial Cancer Epidemiology: New Insights in Survivorship Research
  • UH Cancer Center
Susan M. Schembre, PhD, RD

  • Date: June 19, 2017
  • Title: Next-gen mHealth: Integrating Body Sensors With Smart Technology to Motivate Health Behavior Change
  • UT MD Anderson Cancer Center
Sora Park Tanjasiri, DrPH, MPH

  • Date: June 13, 2017
  • Title: Creating a Cancer Disparities Network for Pacific Islanders: Lessons Learned and Future Directions
  • California State University, Fullerton
John A Shepherd, PhD, CCD

  • Date: May 10, 2017
  • Title: Pushing the radiomic limits of mammography for breast cancer risk, lesion typing, and masking
  • UCSF School of Medicine
John B. Cologne, Ph.D.

  • Date: May 9, 2017
  • Title: Complete Causal Modeling of Observational Data on Liver Cancer
  • Department of Statistics Hiroshima, Japan
Wendy Cozen, D.O., M.P.H.

  • Date: April 17, 2017
  • Title: From Cis to Trans: Molecular Epidemiology in the Precision Medicine Era
  • University of Southern California
Deborah Boggs Bookwalter, Sc.D., PhD

  • Date: April 10, 2017
  • Title: Breast Cancer Risk Prediction for African American Woman
  • Naval Health Research Center
Ming-Yu Ngai, PhD

  • Date: January 17, 2017
  • Title: Development of Novel Chemical Tools for Accessing Unexplored Chemical Spaces
  • Stony Brook University