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Ian J. Okazaki, MD

Ian J. Okazaki, MD
  • Assistant Clinical Professor
    Clinical and Translational Research Program
    University of Hawaii Cancer Center
  • Medical Staff
    Straub Clinic and Hospital


  • MD
    John A. Burns School of Medicine
    University of Hawaii at Manoa

Research Focus

Dr. Okazaki's research fellowship in the Pulmonary-Critical Care Medicine Branch of the NIH focused on mono-ADP-ribosylation of proteins and its effects on cell metabolism. Subsequently as a member of the Division of Hematology, Oncology and Transplantation, he designed clinical trials as part of a translational research project testing autologous large multivalent immunogen (LMI) tumor vaccines for the treatment of patients with renal cell carcinoma and melanoma. This vaccine trial was conducted under an investigational new drug application for the use of LMI in renal cell carcinoma and melanoma. His clinical responsibilities involved patient care in the Hematology/Oncology Outpatient Clinic, with special emphasis on melanoma and urologic malignancies, and the Bone Marrow Transplantation Clinic. Upon returning home to Honolulu, he joined the medical staff at the Straub Clinic and Hospital and continues to pursue his interests as investigator for cancer clinical trials.

Selected Publications

  • Dudek AZ, Mescher MF, Okazaki I, Math VT, Luo X, Curtsinger JM, Miller JS. Autologous large multivalent immunogen vaccine in patients with metastatic melanoma and renal cell carcinoma. Am J Clin Oncol. 2008 Apr;31(2):173-81.
  • Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE, Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood. 2005 Apr 15;105(8):3051-7.
  • Bourgeois C, Okazaki I, Cavanaugh E, Nightingale M, Moss J. Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities. J Biol Chem. 2003 Jul 18;278(29):26351-5.

Publication list via PubMed

Active Grants

  • I. Okazaki, Co-Principal Investigator
    Minority-Based Community Clinical Oncology Program (MBCCOP), University of Hawaii Cancer Center
    January 2011 to Present