Lenora W. M. Loo, PhD
- Assistant Professor (Specialist)
University of Hawai'i Cancer Center
- PhD (Genetics)
University of Hawai'i
Dr. Loo's research is focused on understanding the molecular mechanisms that both initiate and maintain tumorigenesis. Tumors are characterized by the progression of changes to a normal cell that alter the expression of genes involved in the regulation of cell proliferation, apoptosis, adhesion, and genome stability. Characterizing genomic alterations that affect gene expression, such as loss of heterozygosity (LOH), allelic imbalance, or gene copy number gain and loss, may yield important information for the identification of critical genes and genetic pathways that impact tumor specific characteristics. Dr. Loo and colleagues have used whole genome microarray-based assays to demonstrate that the specific intrinsic subtypes of breast cancer are associated with distinct patterns of genomic alterations.
Dr. Loo is also interested in identifying genetic alterations, both gene expression and copy number alterations, that may impact biological events to influence the observed disparities in incidence and survival for breast and colon cancers in different ethnic populations of Hawai'i. Cross-ethnic comparisons of data from the Hawai'i Cancer Registry show that there are differences in the incidence and mortality for different ethnic populations. Factors that contribute to this disparity include socioeconomic status, access to healthcare, stage at diagnosis, and tumor biology. To better understand tumor biology, one of the goals for this study is to identify distinct genetic changes that may impact cancer initiation and progression by altering gene expression patterns in the normal cell. Ultimately, we would like to better understand the biological basis of cancer to improve tailored treatment strategies leading to an increased survival for all individuals with cancer.
- Loo, LWM, Grove, DI, Williams, EM, Neal, CL, Cousens, LA, Schubert, EL, Holcomb, IN, Massa, HF, Glogovac, J, Li, CI, Malone, KE, Daling, JR, Delrow, JJ, Trask, BJ, Hsu, L & Porter,PL (2004) Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Cancer Research, 64(23), 8541-9. PMID: 15574760.
- Loo, LW, Ton, C, Wang, YW, Grove, DI, Bouzek, H, Vartanian, N, Lin, MG, Yuan, X, Lawton, TL, Daling, JR, Malone, KE, Li, CI, Hsu, L & Porter, PL. (2008) Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer. Genes Chromosomes Cancer, 47(12), 1049-66. PMCID: PMC2871767.
- Loo, LW, Wang, Y, Flynn, EM, Lund, MJ, Bowles, EJ, Buist, DS, Liff, JM, Flagg, EW, Coates, RJ, Eley, JW, Hsu, L & Porter, PL (2011) Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women. Breast Cancer Research and Treatment, 127(1), 297-308. PMCID: PMC3224
- Loo LWM, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, Dunklee LM, Church JM, Gryfe R, Weisenberger DJ, Haile RW, Gallinger S, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS ONE. 2012;7(2):e30477. PMCID: PMC 3281844.
- Loo LW, Tiirikainen M, Cheng I, Lum-Jones A, Seifried A, Church JM, Gryfe R, Weisenberger DJ, Lindor NM, Gallinger S, Haile RW, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. (2013)Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer. Genes Chromosomes Cancer. 52(5):450-66. PMID: 23341073.
Publication list via PubMed