Lenora W. M. Loo, PhD
- Assistant Professor (Specialist), Epidemiology Program, University of Hawaiâ€˜i Cancer Center;
- PhD (Genetics), University of Hawaiâ€˜i;
Dr. Loo's research is focused on understanding the molecular mechanisms that both initiate and maintain tumorigenesis. Tumors are characterized by the progression of changes to a normal cell that alter the expression of genes involved in the regulation of cell proliferation, apoptosis, adhesion, and genome stability. Characterizing genomic alterations that affect gene expression, such as loss of heterozygosity (LOH), allelic imbalance, or gene copy number gain and loss, may yield important information for the identification of critical genes and genetic pathways that impact tumor specific characteristics. Dr. Loo and colleagues have used whole genome microarray-based assays to demonstrate that the specific intrinsic subtypes of breast cancer are associated with distinct patterns of genomic alterations.
Dr. Loo is also interested in identifying genetic alterations, both gene expression and copy number alterations, that may impact biological events to influence the observed disparities in incidence and survival for breast and colon cancers in different ethnic populations of Hawaiâ€˜i. Cross-ethnic comparisons of data from the Hawaiâ€˜i Cancer Registry show that there are differences in the incidence and mortality for different ethnic populations. Factors that contribute to this disparity include socioeconomic status, access to healthcare, stage at diagnosis, and tumor biology. To better understand tumor biology, one of the goals for this study is to identify distinct genetic changes that may impact cancer initiation and progression by altering gene expression patterns in the normal cell. Ultimately, we would like to better understand the biological basis of cancer to improve tailored treatment strategies leading to an increased survival for all individuals with cancer.
- Loo LWM, Wang Y, Flynn EM, Lund MJ, Bowles EJ, Buist DS, Liff JM, Flagg EW, Coates RJ, Eley JW, Hsu L, Porter PL. (2011) Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women. Breast Cancer Research and Treatment. 127(1):297-308.
- Loo LWM, Ton CC, Wang Y-W, Grove DI, Bouzek HK, Malone KE, Li CI, Hsu, L, Porter PL. (2008) Identification of Genomic Alterations Differentiating Two Major Histologic Subtypes of Breast Cancer. Genes Chromosomes Cancer. 47(12):1049-1066.
- Hsu, L, Self, SG, Grove, D, Randolf, T, Delrow, JJ, Loo, LWM, Porter, PL. (2005) Denoising Array-based Comparative Genomic Hybridization Data through the Wavelet Method. Biostatistics. 6(2):211-226.
- Loo, LWM, Grove, DI, Neal, CL, Williams, EM, Cousens, LA, Schubert, EL, Holcomb, IN, Massa, H, Glogovac, J, Li, C, Malone, K, Daling, J, Delrow, JJ, Trask, BJ, Hsu, Li, Porter, PL. (2004) Array CGH Analysis of Genomic Alterations in Breast Cancer Sub-Types. Cancer Research 64:8541-8549.
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