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Faculty

Geng-Xian Shi, PhD

Geng-Xian Shi, PhD
  • Assistant Professor
    Natural Products and Experimental Therapeutics Program
    University of Hawaii Cancer Center

Degree

  • PhD, Peking Union Medical College, Beijing
  • MS, Peking Union Medical College, Beijing

Research Focus

Dr. Shi's research studies the regulatory role of a mitochondrial protein, Bcl-2 inhibitor of transcription (Bit1), on cell death and survival by cell adhesion and detachment. In particular, his work is to elucidate Bit1-dependent signal transduction pathways in tumor cell migration, invasion and metastasis.

Dr. Shi also investigates the role of R-Ras in endothelial barrier function. R-Ras has been shown to promote endothelial barrier integrity and play a critical role in the angiogenesis of tumor. His work will elucidate the signaling mechanisms contributing to R-Ras signaling-mediated stabilization of the endothelial barrier in tumorgenecity.

Previously, Dr. Shi's work focused on the elucidation of signaling mechanisms that contribute to Ras related GTPase, Rit and Rin GTPases-mediated cell differentiation and survival. Oncogenic mutations of Ras proteins contribute to the tumorigenesis of almost every type of human cancers. Indeed, Rit mutations have also been identified from human hepatocellular carcinoma and myeloid malignancies, and Noonan syndrome as well. In collaboration with the investigator from Broad Institute, they have successfully identified several somatic mutations for Rit GTPase from human lung adenocarcinoma that are mutually exclusive with all other known lung adenocarcinoma driver mutations.

Selected Publications

  • Berger AH, Imielinski M, Duke F, Wala J, Kaplan N, Shi G-X, Andres DA and Meyerson M. Oncogenic RIT1 mutations in lung adenocarcinoma, Oncogene, 2014 in press.
  • Shi G-X*, Cai W and Andres DA. (2013) Rit subfamily small GTPases: Regulators in neuronal differentiation and survival, Cell Signaling, 2013 Oct; 25(10): 2060-2068. doi: 10.1016/j.cellsig.2013.06.002. Epub 2013 Jun 11, PMID: 23770287.
  • Shi G-X*, Cai W and Andres DA. (2012) Rit-mediated Stress Resistance Involves a p38-Mitogen- and Stress-activated Protein Kinase 1 (MSK1)-dependent cAMP Response Element-Binding Protein (CREB) Activation Cascade. Journal of Biological Chemistry, 2013 Nov 16; 287(47): 39859-68. doi: 10.1074/jbc.M112.384248. Epub 2012 Oct 4. PMID: 23038261.
  • Shi G-X*, Jin L and Andres.(2011) A Rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress, Molecular and Cellular Biology, 2011 May; 31(10): 1938-1948. doi: 10.1128/MCB.01380. Epub 2011 Mar 28. PMID: 21444726.
  • Shi G-X*, Jin L and Andres DA. (2010) Src-dependent TrkA Transactivation Is Required for PACAP38-mediated Rit Activation and Neuronal Differentiation. Molecular Biology of the Cell, 2010 May 1; 21(9) : 1597-1608. doi: 10.1091/mbc.E09-12-1033. Epub 2010 Mar 10. PMID: 20219970.

Publication list via PubMed