University of Hawai‘i at Manoa Homepage

Faculty

Ingo Lange, PhD

Ingo Koomoa-Lange, PhD
  • Full Member
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Academic Appointments

  • Instructor
    The Daniel K. Inouye College of Pharmacy
    Department of Pharmaceutical Sciences
    University of Hawaii at Hilo
  • Adjunct Professor
    Division of Natural Sciences and Mathematics at Chaminade
    Chaminade University of Honolulu

Degrees

  • PhD, University of Erlangen-Nuremberg

Research Focus

My research focuses on understanding how ion channel signaling steers physiological and pathophysiological processes within and between cells. My research is focused on identifying the molecular components that regulate the spatial and temporal dynamics of calcium signals between the plasma membrane and organelles, and the resulting physiological consequences (e.g. regulation of transcription, reprograming the cell fate including cell deaths). One of my main areas of research is to understand these processes and their contribution to the malignant progression of Neuroblastoma and also to the development of multi-drug resistance in Neuroblastoma. Another area of research that I am interested in investigates the dynamic signaling cascades that are induced by pathogens and pathochemical stimuli in the cells of the innate immune system. Recently, I have been working on the pathways that are shared among the two fields, pediatric oncology and innate immunology, and thereby study the interplay of innate immune cells in the tumor microenvironment.

The laboratory uses a combination of high-content imaging, genomic analysis, as well as molecular, biochemical & biophysical techniques.

Selected Publications

  • Beceiro S, Radin JN, Chatuvedi R, Blanca Piazuelo M, Horvarth DJ, Cortado H, Dixon B, Cheng G, Lange I, Koomoa D-LT, Wilson KT, Scott Algood HM, Partida-Sánchez S. (2016). TRPM2 ion channels regulate NADPH oxidase activity and macrophage polarization upon Helicobacter pylori infection. Mucosal Immunol; Jul 20. doi: 10.1038/mi.2016.60.
  • Lange I, Moschny J, Kerimov VN, Khutsishvili M, Atha DE, Borris RP, Koomoa D-L. (2016). Scrophularia orientalis Extract Induces Calcium signaling and Apoptosis in Neuroblastoma cells. Int J Oncol; Feb 3. doi: 10.3892/ijo.2016.3373.
  • Lange I, Koomoa D-LT. (2014). Mycn promotes trpm7 expression and cell migration in neuroblastoma through a process that involves polyamines. FEBS Open Bio; Oct 30;30;4:966-75.
  • Lange I, Feith DJ, Mocz G, Geerts D, Koster J, Bachmann AS. (2014). Novel interaction between ornithine decarboxylase and sepiapterin reductase regulates neuroblastoma cell proliferation. J Mol Biol; Jan 23;426(2):332-46.
  • Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig S, Penner R. (2009). TRPM2 functions as lysosomal Ca2+ release channel in b-cells. Sci Signal; Volume 2, Issue 71, May 19, p. ra23 (Cover of Science Signaling).

Publication list via PubMed

Recently Completed Grants

  • I. Lange, PI
    Alex's Lemonade Stand Foundation
    ID# 28075
    "Molecular mechanism and development of therapeutic strategies targeting MYCN-induced calcium signaling in advanced Neuroblastoma"
    06/01/14-06/30/17