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Linda L. Wong, MD

Linda L. Wong, MD
  • Professor
    Clinical Sci & Translational Res
    University of Hawaii Cancer Center
  • Professor
    Department of Surgery
    John A. Burns School of Medicine
  • Director
    Liver Transplant Program
    The Queen's Medical Center


  • MD
    University of California, Irvine
  • General Surgery Residency
    Cedars-Sinai Medical Center
  • Transplant Fellowship, California-Pacific Medical Center

Research Focus

Dr. Wong is a liver transplant and hepatobiliary surgeon who founded and heads the only liver transplant program in the state of Hawaii. She is also currently building the state's only multidisciplinary hepatobiliary program, Dr. Wong has been participating in research activities related to liver disease and cancer for the past 17 years. She believes a better understanding of these diseases will allow for earlier detection, better treatment and ultimately prevention of liver cancer.

Viral hepatitis patients are those most prone to developing hepatobiliary cancers and Hawaii has the highest incidence of hepatobiliary cancer in the US. Through the clinical partnership with her surgery center, researchers have the unique opportunity to study viral carcinogenesis and potentially prevent cancer in the group with the highest risks.

Hawaii's high incidence of viral hepatitis is primarily due to immigrants from Asian and Pacific Island nations in which hepatitis B is endemic. There are also great racial disparities among Pacific Islanders in terms of treatment of both viral hepatitis and liver cancer. Dr. Wong is dedicated to solving hepatobiliary disease collaboratively, because she knows she and her colleagues can have the greatest impact on care for their patients by working together.

Selected Publications

  • Kim C, Wong LL, Kwee S, Hernandez BY.(2013).Alpha-fetoprotein testing for hepatocellular carcinoma in nonalcoholic steatohepatitis. Open J Gastroenterol, PP. 49-54. doi: 10.4236/ojgas.2013.31008.
  • Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL. (2013).. Elucidating the DNA Methylation Landscape in Hepatocellular Carcinoma. PLoS One, 8(2):e55761. doi:10.1371. PMID:23437062.
  • Kwee SA, Chan O, Hernandez B, Wong LL. (2012).Choline Kinase Alpha and Hexokinase-2 Protein Expression in Hepatocellular Carcinoma: Association with Survival. PLoS One, 7:e46591. PMID:23071593.
  • Wong LL, Lopez K, Kuwada S. (2013).Needle track seeding of hepatocellular cancer can be devastating after liver transplantation. Clin Transplant, 27(4): 400-6. doi: 10.1111/ctr.12160. PMID: 23837571.
  • Hernandez BY, Zhu XM, Chan O, Kwee S, Okimoto G, Tsai N, Albright C, McGlynn K, Alterkruse S, Yu H, Wong LL. (2013).Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma. Cancer Epidem Biomar, PMID: 23983238.

Publication list via PubMed

Active Grants

  • L.L. Wong, Subcontract Co-Investigator, (S. Kwee/G. Okimoto, Principal Investigators)
    5 R01 CA161209-02
    NCI / The Queen's Medical Center
    "Functional Genomics and Molecular Imaging of Liver Disease and Cancer"
    Using positron emission tomography/computed tomography (PET/CT) of liver cancer tissue, this study will perform integrated analysis of high-dimensional microarray data to enhance the identification of genes, pathways, and novel biomarkers for the early diagnosis of liver cancer.
  • L.L. Wong, Co-Investigator, (H. Yu, Principal Investigator)
    7 R01 CA138698-03
    Epidemiologic Study of Hepatocellular Carcinoma in the US
    This project will investigate the causes of hepatocellular carcinoma (HCC) among Americans and find the reasons responsible for the rise of HCC incidence in the US. The study plan to enroll 1,250 incident HCC cases and 2,500 population controls in the states of Connecticut and New Jersey.
    6/1/2012- 5/31/2016
  • L.L. Wong, Co-Investigator, (M. Carbone, Principal Investigator)
    2 P30 CA071789-13
    Cancer Center Support Grant (CCSG): University of Hawaii Cancer Center
    The major goal of this project is to continue to lower cancer incidence and improve the care of cancer patients in Hawaii and elsewhere by attempting to understand reasons for the remarkable ethnic-related cancer associations found in the region.
    7/1/97 – 8/31/17