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Sandi Alexander Kwee, PhD, MD

Sandi Alexander Kwee, MD
  • Full Member
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Clinical Adjunct Professor
    Cancer Biology Program
    University of Hawaii Cancer Center
  • Associate Professor
    John A. Burns School of Medicine, University of Hawaii at Manoa
  • Director for PET Research
    The Queen's Medical Center


  • MD
    University of Pittsburgh
  • MSc
    University of Hawaii
  • PhD
    University of Hawaii
  • Internal Medicine
    John A. Burns School of Medicine
    University of Hawaii at Manoa
  • Nuclear Medicine and Nuclear Cardiology
    University of Washington, Seattle

Research Focus

Dr. Kwee is the principal investigator of NCI funded clinical trials (NCT00928252 and NCT00928174) evaluating an investigational positron tomography (PET) diagnostic for liver and prostate cancers. Recent work has also involved the analysis of free circulating nucleic acids as a complement to imaging biomarkers, PET-guided radiation therapy planning, and using PET imaging as a means to annotate tissue gene expression profiling. Another research-relevant interest is biomedical ethics.

Selected Publications

  • Kwee SA, Lim J, Watanabe A, Kromer-Baker K, Coel MN. Prognosis Related to Metastatic Burden Measured by 18F-Fluorocholine PET/CT in Castration-Resistant Prostate Cancer. J Nucl Med. 2014 Mar 27;55(6):905-910.
  • Kwee SA, Hernandez B, Chan O, Wong L. Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival. PLoS One. 2012;7(10). e46591. PMCID:
  • Kwee S, Song MA, Cheng I, Loo L, Tiirikainen M. Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer. Clin Transl Sci. 2012 Feb;5(1):65-70.
  • Kwee SA, Ko JP, Jiang CS, Watters M, Coel MN. Solitary Brain Lesions Enhancing at MR Imaging: Evaluation with Fluorine 18 Fluorocholine PET. Radiology. 2007 Aug;244(2):557-65.Kwee SA, Coel MN, Lim J, Ko JP. Prostate cancer localization with 18fluorine fluorocholine positron emission tomography. J Urology. 2005 Jan;173(1):252-5.

Publication list via PubMed

Active Grants

  • S. Kwee, Principal Investigator
    NIH, NCI R01CA161209
    "Functional Genomics and Molecular Imaging of Liver Disease and Cancer"
    July 2011 – April 2016