About Us

Our lab studies molecular genetics and signaling pathways during liver cancer growth to develop new therapies to treat this deadly disease.

Based on genomic studies from human liver cancers using both in vitro cell culture system and in vivo modeling, we are characterizing the functional contribution of major signaling and metabolic cascades that contribute to hepatocarcinogenesis. We are studying pathways that include:

  • PI3K/AKT/mTOR
  • Hippo/Yap
  • Notch
  • Ras/MAPK
  • β-catenin signaling.

We are studying the genetic and biochemical crosstalk among these pathways and how they regulate liver cancer development, and we are testing novel, targeted therapies for liver cancer treatment using drugs which specifically target these pathways.

Translational studies of human liver cancers: bedside to the bench, and back to the bedside.
Translational studies of human liver cancers:  bedside to the bench, and back to the bedside.