COVID-19: LifeDNA and University of Hawaiʻi Collaborate on Studying Why Certain Populations Are Hit Harder

Research focuses on ACE2 receptor, probing the role of genetics in both susceptibility to infection and severity of response

by LIfeDNA
April 2, 2020

Download or view original press release by LifeDNA

Life DNA logoLifeDNA, Inc. , a pioneering personal genomics company, has initiated a coronavirus study aimed at understanding why certain individuals and racial/ethnic groups are more prone to the infection and may suffer a more severe course of COVID-19.

“COVID-19 has upended daily life for citizens around the globe,” said Cyril Moukarzel, CEO of LifeDNA, Inc. “Based on genetics, certain individuals and populations may be impacted more severely. LifeDNA’s scientists are working tirelessly to add to the body of knowledge regarding the effect of these genetic variations.”

Honolulu-based LifeDNA is collaborating with molecular epidemiologist Maarit Tiirikainen, Ph.D., Associate Professor at the University of Hawaiʻi at Mānoa . The study will initially focus on the multi-ethnic population of Hawai‘i and genetic variants of the ACE2 gene as they relate to infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19.

Maarit Tiirikainen

“There have been major differences in the rates of SARS-CoV-2 infection and the severe disease between the different geographic regions since the beginning of the COVID-19 pandemic, even among young individuals,” Dr. Tiirikainen said. “Epidemiological studies—so-called Genome Wide Association Studies (GWAS)—indicate that populations carry different variants of the ACE2 gene. This variation in the gene coding for the ACE2 receptor may have an effect on the number of ACE2 receptors on the lung cells, as well as on how effectively the virus binds to the receptor. There may also be genetic differences in immune and other important genes explaining why some people get more sick than others.”

For more than three years now, LifeDNA has been utilizing published GWAS data to provide reports on the association of genetic variants to various human traits. In this global health crisis, LifeDNA will focus its scientific resources on determining why certain individuals and ethnic populations seem more prone to the SARS-CoV-2 infection and may also have a more severe course of the COVID-19 disease. The differences in the severity of the disease may also have an effect on future lung cancer incidences in different populations, especially when augmented by smoking.

The genotyping for the study will be done at the Kakaʻako Genomics and Bioinformatics Shared Resource (co-directed by Tiirikainen and Youping Deng, professor of quantitative health sciences at the UH Mānoa John A. Burns School of Medicine ) at the University of Hawai‘i Cancer Center. LifeDNA expects that the findings of its study will allow for identifying the most vulnerable individuals and populations ahead of time in future SARS virus-family outbreaks. The company also envisions pharmacogenomics collaborations on life-enhancing and lifesaving preventive therapeutics, such as those utilizing CRISPR-Cas9 gene editing technology. While LifeDNA has yet to initiate formal partnership dialogue, companies with this relevant domain expertise include CRISPR Therapeutics AG, Editas Medicine, Inc. and Intellia Therapeutics, Inc.