Michele Carbone, MD, PhD

Michele Carbone, MD, PhD

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Director, Thoracic Oncology, University of Hawaiʻi Cancer Center
Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center

Academic Appointment(s):
Professor (Researcher), University of Hawaiʻi Cancer Center, University of Hawaiʻi at Mānoa
Professor, Department of Pathology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa

Degree(s):
1984 - MD, Medical School of Rome "La Sapienza", Italy
1993 - PhD, Medical School of Rome "La Sapienza", Italy
1988 - University of Rome, Italy - Medical Board Certifications in Anatomic Pathology
1999 - University of Chicago, USA - Medical Board Certifications in Anatomic Pathology

Honors

2018 - The iMiG Wagner Medal, the highest honor presented by the iMiG to a leader in the field for "discovering the role of genetics in the pathogenesis of mesothelioma."
2018 PAIR (Prize in American-Italian Relations) in Technical and Technological Science for "overcoming the boundaries of science and the development of technology, in order to improve the quality of human life and protection of the environment"
2014 - Mesothelioma Applied Research Foundation-Pioneer Award for "discovering the BAP1 cancer syndrome"
2008 - Landon Foundation-AACR INNOVATOR Award for International Collaboration in Cancer Research for "discovering the causes of the Mesothelioma epidemics in Cappadocia, Turkey"
2001 - Knight of the Republic of Italy (Cavaliere della Repubblica)

Research Focus

h-index: 71 (Publications on Google scholar)

Investigating an epidemic of mesothelioma in remote villages in Cappadocia, Carbone first hypothesized and then proved that it was caused by inherited genetic susceptibility to carcinogenic mineral fibers present in the environment (Roushdy-Hammady I,..& Carbone M, The Lancet, 2001; Dogan UA,..& Carbone M, Cancer Res, 2006; Carbone M, et al., Proc Natl Acad Sci USA, 2011). Subsequently, Carbone discovered that inherited mutations of the BRCA1-associated protein 1 (BAP1) caused mesothelioma and other environmentally-related cancers (Testa JR,..& Carbone M, Nat Genet, 2011), a condition he named “The BAP1 cancer syndrome” (Carbone M, et al., J Transl Med, 2012 and Nat Rev Cancer, 2013). He elucidated the molecular mechanisms by which BAP1 modulates gene-environment interaction in human carcinogenesis (Bononi A,..& Carbone M, Nature, 2017; Bononi A,..& Carbone M, Cell Death Differ, 2017), and elucidated mechanisms that regulate BAP1 and asbestos GxE interaction and the clinical implications (Patorino S., et al., JCO 2018; Carbone M., et al., Nat Rev Cancer 2020; Carbone et al., Cancer Discovery 2020; Xue J et al., PNAS 2020). Most recently Carbone discovered additional germline mutations that predispose to mesothelioma and GxE carcinogenesis (Bononi A. et al., PNAS 2020 in press).

Clinical: I am board-certified in Anatomic Pathology (both in Italy and the U.S.) and specialize in pleural pathology and mesothelioma.

Selected Publications

Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, Carparelli L, Ferro A, Nasu M, Kim J-H, Suarez JS, Xu R, Tanji M, Takinishi Y, Minaai M, Novelli F, Pagano I, Gaudino G, Pass HI, Groden J, Grzymski JJ, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H, Carbone M. Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma. Proc Natl Acad Sci U S A. 2020, In press. Impact Factor: 9.4

Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, Tanji M, Novelli F, Pastorino S, Xu R, Caroccia N, Dogan AU, Pass HI, Tognon M, Pinton P, Gaudino G, Mak TW, Carbone M, Yang H. (2020). Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy. Proc Natl Acad Sci U S A, 117:25543-25552, 2020. doi: 10.1073/pnas.2007622117. PMID: 32999071; PMCID: PMC7568322. Impact Factor: 9.4

Carbone M, Arron ST, Beutler B, Bononi A, Cavenee W, Cleaver JE, Croce CM, D’Andrea A, Foulkes WD, Gaudino G, Groden JL, Henske EP, Hickson ID, Hwang PM, Kolodner RD, Mak TW, Malkin D, Monnat RJ Jr, Novelli F, Pass HI, Petrini JH, Schmidt LS, Yang H. (2020). Tumour predisposition and cancer syndromes as models to study gene X environment interactions. Nat Rev Cancer, May 29, (Perspective). doi: 10.1038/s41568-020-0265-y. Online ahead of print. Impact Factor: 53.0

Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G. (2020). Biological mechanisms and clinical significance of BAP1 mutations in human cancer. Cancer Discovery, 10:1-18. Impact Factor 29.5

Carbone M, Adusumilli PS, Alexander HR, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P; Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI. (2019). Mesothelioma: Scientific Clues for Prevention, Diagnosis, and Therapy. Ca Cancer J Clin, 69:402-429. doi.org/10.3322/caac.21572. Impact Factor: 223.6

Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, MNapolitano A, Gaudino G, Morris ,Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinto0n P, Carbone M. (2017). BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature, 546:549-553. doi: 10.1038/nature22798. Impact Factor: 42.8

Publication list via PubMed

Active Grants

M. Carbone, PI
UH Foundation through unrestricted donations from Honeywell Int. Inc., Riviera United-4-a Cure, Maurice and Joanna Sullivan Family Foundation
"Pathogenesis of Malignant Mesothelioma”
07/01/10-Open

M. Carbone, Contact PI; H. Yang, Co-PI
1R01CA237235-01A1
NCI
"Mechanisms of BAP1 activity in human cancer development"
12/13/19-11/30/24

M. Carbone, Contact PI, H. Yang (U. Hawaiʻi), Grzymski, DRI, Nevada, Co-PIs
1R01ES030948-01
NIEHS
"Influence of germline mutations on susceptibility to environmental carcinogens"
08/15/19-06/30/22

H. Yang; Initiating PI, M. Carbone, H.I. Pass, T. Mak, J. Fert-Bober, partnering PIs
W81XWH-16-1-0441/ CA150671P1
DoD
Peer Reviewed Cancer Research Program Translational Team Science Award
"HMGB1 and Its Isoforms as Biomarkers For Mineral Fiber Exposure and MM Detection"
09/01/16-08/31/21 (presently on no cost extension)

M. Carbone, PI
5R01CA198138-05
NCI
"Germline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early Detection"
07/01/15-06/30/21 (presently on no cost extension)

Philanthropy: Support from the University of Hawaiʻi Foundation that received unrestricted donations to support my mesothelioma research from Riviera United-4-a Cure Foundation, and from Honeywell International Inc.