Owen Chan, MD, PhD

Owen Chan, MD, PhD

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Director, Pathology Core Shared Resource, University of Hawaiʻi Cancer Center
Associate Member, Cancer Biology, Translational and Clinical Research, University of Hawaiʻi Cancer Center

Academic Appointment(s):
Assistant Professor (Assistant Researcher), Translational and Clinical Research, University of Hawaiʻi Cancer Center
Assistant Clinical Professor, Department of Pathology, John A. Burns School of Medicine, University of Hawaiʻi

MS, Biology and MPhil, Biology, Yale University, New Haven, CT
PhD, Immunobiology, Yale University, New Haven CT
MD, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
Postdoctoral Fellowship, Immunology, University of California, San Francisco, CA
Placental Pathology Fellowship, University of California, San Diego, CA
Combined Anatomic Pathology / Clinical Pathology Residency, University of California, San Diego, CA
Hematopathology Fellowship, Stanford University, Stanford, CA
Gastrointestinal/Liver Pathology Fellowship, Cedars-Sinai Medical Center, Los Angeles, CA

Research Focus

I am interested in translational research, especially as it pertains to the tumor inflammatory microenvironment. Currently, I collaborate with multiple members of the University of Hawaiʻi Cancer Center, where I utilize my training as a pathologist and basic science researcher. I also serve as the Director of the Pathology Shared Resource.

Selected Publications

Hernandez BY, Rahman M, Loo LWM., Chan OTM, Horio D, Morita S, Bryant-Greenwood G. (2021). BRAFV600E, hypothyroidism, and human relaxin in thyroid carcinogenesis. J Cancer Res Clin Oncol;Jan;147(1):183-194. PMID: 32995956; PMCID: PMC7855918.

Maskarinec G, Ju D, Shvetsov YB, Horio D, Chan O, Loo LWM, Hernandez BY. (2020). Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort. Cancer Epidemiol;April ;65:101685. PMID: 32058311, PMCID: PMC7131953.

Furuya H, Hayashi K, Shimizu Y, Kim N, Tsukikawa Y, Chen R, Sun Y, Chan OTM, Pagano I, Peres R, Hokutan K, Igari F, Chan KS, Rosser CJ. (2020). Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model. J Transl Med;February 5;18(1):57. PMID: 32024545, PMCID: PMC7003426.

Furuya H, Chan OTM, Hokutan K, Tsukikawa Y, Chee K, Kozai L, Chan KS, Dai Y, Wong RS, Rosser CJ. (2019). Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma. Diagnostics (Basel);Dec 28;10(1):14. PMID: 31905599; PMCID: PMC7168167.

Li ZW, Su B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM. (2019). GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. Gastroenterology;June;156(8):2297-2312. PMID: 30836096, PMCID: PMC6628260.

Publication list via PubMed