Peter R. Hoffmann, PhD, MSPH
Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center
Academic Appointment(s):
Professor, Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa
Degree(s):
PhD, Immunology and Microbiology, University of Colorado
MSPH, Public Health, University of Hawaiʻi at Mānoa
Research Focus
Immunology, Inflammation, Inflammation associated cancer
Selected Publications
Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urshcitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. (2021). Upregulated ethanolamine phospholipid synthesis by selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metabol; Jan 20;47:101170. doi: 10.1016/j.molmet.2021.101170.
Marciel MP, Khadka V, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter M, Hoffmann PR. (2018). Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget; Feb 3;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 2.
Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR. (2018). Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med:Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6. PMID 29210197.
Fredericks GJ, Hoffmann FW, Rose AH, Osterheld H, Hess FM, Mercier F, Hoffmann PR. (2014).Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/Selenoprotein K complex. Proc Natl Acad Sci;Nov 18;111(46):16478-16483.
Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. (2013). Calpastatin prevents NF-B mediated hyperactivation of macrophages and attenuates colitis. J Immunol;Oct 1;191(7):3778-88.
Publication list via PubMed
Active Grants
P. Hoffmann, Principal Investigator
NIH/NIAID
1R01AI147496
"The role of selenoprotein I in phospholipidethanolamine dependent mechanisms that regulate T cell activation"
The major goal of this project is to determine how the selenoprotein I enzyme is involved in T cell activation that drive immune responses to vaccination and viral infection.
Specific Aim 1. To determine the role of SELENOI in PE synthesis in T cells and its requirement for establishing balanced membrane lipid composition and promoting robust TCR induced signals.
Specific Aim 2. To elucidate mechanisms by which SELENOI promotes effective T cell proliferation and differentiation.
Specific Aim 3. To determine the in vivo role of SELENOI in T cell responses to vaccines and a viral pathogen.
6/01/2019 - 5/31/2024
P. Hoffman, Program Coordinator (salary compensation only); Nichols, PI
NIH/NIGMS
2 P20GM103466
“INBRE IV - Hawaii Statewide Research and Education Partnership”
This is the third cycle of a grant to the state of Hawaii program for building IDeA Networks in Biomedical Research Excellence.
Specific Aim 1. To manage and support the building of research infrastructure and development of human resources in our state’s biomedical research network
Specific Aim 2. To coordinate and administer the collective actions of Cores, Programs, and Activities
5/01/2013-04/30/2023
P. Hoffman, Principal Investigator
NIH/NIAID
2R01A1089999
“Selenoprotein K modulates calcium-dependent signaling in immune cells”
The major goal of this project is to determine molecular mechanisms by which Selk regulates immune cell function and its role in palmitoylation of key proteins participating in these functions.
Specific Aim 1. Determine the mechanisms by which Selk regulates palmitoylation of the IP3R.
Specific Aim 2. Identify cellular proteins that require Selk for palmitoylation and determine how palmitoylation regulates their function.
Specific Aim 3. To determine how Selk expression is regulated in human T cells and how this affects IP3R expression and T cell function.
12/01/2015 - 11/30/2021 -No cost extension
