Peter R. Hoffmann, PhD, MSPH
Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center
Academic Appointment(s):
Professor, Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa
Degree(s):
PhD, Immunology and Microbiology, University of Colorado
MSPH, Public Health, University of Hawaiʻi at Mānoa
Research Focus
Immunology, Inflammation, Inflammation associated cancer
Selected Publications
Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urshcitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. (2021). Upregulated ethanolamine phospholipid synthesis by selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metabol; Jan 20;47:101170. doi: 10.1016/j.molmet.2021.101170.
Marciel MP, Khadka V, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter M, Hoffmann PR. (2018). Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget; Feb 3;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 2.
Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR. (2018). Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med:Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6. PMID 29210197.
Fredericks GJ, Hoffmann FW, Rose AH, Osterheld H, Hess FM, Mercier F, Hoffmann PR. (2014). Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/Selenoprotein K complex. Proc Natl Acad Sci;Nov 18;111(46):16478-16483.
Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. (2013). Calpastatin prevents NF-B mediated hyperactivation of macrophages and attenuates colitis. J Immunol;Oct 1;191(7):3778-88.
Publication list via PubMed
Active Grants
P. Hoffmann, PI
2 P20GM103466
NIH/NIGMS
"Hawaii IDeA Network for Biomedical Research Excellence (HI-INBRE V)."
This is a collaborative outreach partnership between the University of Hawaii at Manoa, the state’s Primarily Undergraduate Institutions and University of Hawaii Community Colleges. The long-term goals are to strengthen and expand the biomedical research capacity throughout the state of Hawaii, to nurture research collaborations within Hawaii and throughout the greater INBRE network, to enhance professional development of faculty and community college and undergraduate students at Hawaii INBRE partner institutions.
5/1/2023 – 4/30/2028
Hoffmann and Pitts, MPIs
1R21NS133944
NIH/NINDS
"The role of Selenoprotein I in mitigating neurodegeneration."
For this project, Dr. Hoffmann has teamed up with a Junior Investigator, Dr. Matt Pitts, for an exploratory, innovative research project that will lead to submission of an MPI R01 grant proposal within 2 years.
7/1/2023 – 6/30/2025
P. Hoffmann, PI
1R01AI147496
NIH/NIAID
"The role of selenoprotein I in phospholipidethanolamine dependent mechanisms that regulate T cell activation."
The 5-year renewal for this R01 project will be submitted in 2023.
6/1/2019 – 5/31/2024
