Sandi Alexander Kwee, PhD, MD

Sandi Alexander Kwee, MD, PhD, MSc

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Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center

Academic Appointment(s):
Associate Professor (Associate Researcher), Cancer Biology Program, University of Hawaiʻi Cancer Center
Clinical Associate Professor, Department of Medicine, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa
Director for PET Research, The Queen's Medical Center

Degree(s):
MD, University of Pittsburgh
PhD, Biomedical Sciences, University of Hawaiʻi
MSc, Clinical Research, University of Hawaiʻi
Internal Medicine, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa
Nuclear Medicine and Nuclear Cardiology, University of Washington, Seattle

Research Focus

Dr. Kwee is the principal investigator of NCI funded clinical trials (NCT00928252 and NCT00928174) evaluating an investigational positron tomography (PET) diagnostic for liver and prostate cancers. Recent work has also involved the analysis of free circulating nucleic acids as a complement to imaging biomarkers, PET-guided radiation therapy planning, and using PET imaging as a means to annotate tissue gene expression profiling. Another research-relevant interest is biomedical ethics.

Selected Publications

Kwee S, Tiirikainen M, Sato M, Acoba J, Wei R, Jia W, Le Marchand L, Wong L. (2019). Transcriptomics Associates Molecular Features with 18 F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma. Cancer Research. Apr 1; 79(7):1696-1704. PMC6494445

Kwee SA, Wong L, Chan OTM, Kalathil S, Tsai N. (2018). PET/CT with (18)F Fluorocholine as an Imaging Biomarker for Chronic Liver Disease: A Preliminary Radiopathologic Correspondence Study in Patients with Liver Cancer. Radiology. Apr;287(1):294-302. PMC5860972

Kwee SA, Lim J, Watanabe A, Kromer-Baker K, Coel MN. (2014). Prognosis Related to Metastatic Burden Measured by 18F-Fluorocholine PET/CT in Castration-Resistant Prostate Cancer. J Nucl Med. Mar 27;55(6):905-910. PMC4424048

Kwee S, Song MA, Cheng I, Loo L, Tiirikainen M. (2012). Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer. Clin Transl Sci. Feb;5(1):65-70. PMC3500883

Kwee SA, Ko JP, Jiang CS, Watters M, Coel MN. (2007). Solitary Brain Lesions Enhancing at MR Imaging: Evaluation with Fluorine 18 Fluorocholine PET. Radiology. Aug;244(2):557-65.