Guoxiang Xie, MD
Affiliate Member, University of Hawaiʻi Cancer Center
Academic Appointment(s):
Assistant Specialist (Assistant Professor), University of Hawaiʻi Cancer Center, University of Hawaiʻi at Mānoa
Degree(s):
MS, Applied Chemistry, East China University of Science and Technology, China
MD, Pharmaceuticals, Shanghai Jiao Tong University, China
Postdoctoral Fellowship, Metabolomics, University of Carolina at Greensboro
Research Focus
Dr. Xie joined the UH Cancer Center as an assistant specialist in the Metabolomics Shared Resource since 2013. He received his MD (Pharmaceuticals) from Shanghai Jiao Tong University, Shanghai, China in 2007. Before joining the UH Cancer Center, he was a research scientist in the Center for Translational Biomedical Research at the University of North Carolina at Greensboro. Dr. Xie's current research focuses on conducting comprehensive metabolomics studies to 1) identify the metabolite markers for disease diagnosis and stratification, 2) define the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to metabolic disorders and gastrointestinal cancer, and 3) define the molecular mechanisms of gastrointestinal carcinogenesis and bile acid metabolism.
Selected Publications
Xie GX, Wang XN, Jiang RQ, Zhao AH, Yan JY, Zheng XJ, Huang FJ, Liu X, Panee J, Rajani C, Yao C, Yu H, Jia WP, Sun BC, Liu P, Jia W. (2018). Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure. EBioMedicine; 37:294-306.
Jia W, Xie GX, Jia, WP. (2018). Bile acids and microbiome cross-talk and its impact on gastrointestinal carcinogenesis. Nature Reviews Gastroenterology and Hepatology; 15(2):111-128.
Xie GX, Wang XN, Huang FJ, Zhao AH, Chen WL, Yan JY, Zhang YJ, Lei S, Ge K, Zheng XJ, Liu JJ, Su MM, Liu P, Jia W (2016). Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. International Journal of Cancer, 139(8):1764-75. PMID: 27273788.
Xie GX, Wang, YX, Wang, XN, Zhao, AH, Chen, TL, Ni, Y, Wong, L, Zhang, H, Zhang, J, Liu, C, Liu, P, Jia, W. (2015). Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC-MS/MS. Journal of Proteome Research,14 (2): 850-859. PMID: 25581415.
Xie GX, Zhong W, Li H, Li Q, Qiu YP, Zheng XJ, Chen HY, Zhao XQ, Zhang SC, Zhou ZX, Zeisel SH, Jia W. (2013). Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB Journal, 27(9):3583-93. PMID: 23709616.
Publication list via PubMed
Active Grants
Guoxiang Xie, Co-Investigator; W. Jia, PI
NIH/NCI
1U01CA188387-01A1
"Gut microbiota mediated bile acid alterations in hepatic carcinogenesis"
08/01/15 - 07/31/20
