Haining Yang, MD, PhD

Haining Yang, MD, PhD

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Full Member, Cancer Biology Program, University of Hawaiʻi Cancer Center

Academic Appointment(s):
Researcher (Professor), University of Hawaiʻi Cancer Center, University of Hawaiʻi at Mānoa

Degree(s):
MD, Shandong Medical University, P.R. China
PhD, Shandong University, P.R. China

Honors

2018 - iMig (International Mesothelioma Research Group) Research Award
2008 - Landon AACR Innovator Award for International Collaboration in Cancer Research
2005 - EU Marie Curie Scholarship by the European Commission Marie Curie Actions Program

Research Focus

Dr. Haining Yang's research work focuses on the pathogenesis of mesothelioma, a malignancy often related to exposure to asbestos or other carcinogenic mineral fibers. Her research goal is to find novel strategies for mesothelioma early detection, prevention and therapy. During years of study, Dr. Yang has discovered some key mechanisms of asbestos-induced carcinogenesis. She found that asbestos induces cell necrosis, causing the release of a critical factor called High Mobility Group Box 1 protein (HMGB1). HMGB1 functions as the "master switch" that when turned on, kick starts a series of inflammatory responses that over time lead to malignant transformation of mesothelial cells and mesothelioma development. Moreover, she found that mesothelioma cells that grow out of an HMGB1-rich environment are "addicted" to HMGB1 and require it for tumor growth and progression. Therefore, Dr. Yang is exploring targeting HMGB1 as a novel therapeutic strategy for mesothelioma. Dr. Yang and her research team found that both mesothelioma patients and asbestos-exposed individuals have significantly higher serum HMGB1 levels compared to heavy smokers or healthy people which suggested that HMGB1 can be a sensitive and specific biomarker to detect asbestos exposure and to identify mesothelioma patients.

Besides the studies on HMGB1, Dr. Yang in collaboration with Dr. Michele Carbone, discovered that heterozygous germline BAP1 mutations predispose to malignant mesothelioma. These findings opened a new research field studying the mechanisms of gene-environment interaction in causing mesothelioma, and led to the discovery of a new cancer syndrome that was named the "BAP1 cancer syndrome".

Dr. Yang's research is funded by the National Cancer Institute, National Institute of Environmental Health Sciences (NIEHS), the V-Foundation and the Department of Defense (DoD). Dr. Yang received the EU Marie Curie Scholarship from the European Commission Marie Curie Actions Program in 2005. She was one of the recipients of the American Association for Cancer Research (AACR) Innovative Landon Award for International Collaboration in Cancer Research in 2008. She also received the iMig Research Award in 2018. She has two approved and two pending patents.

Selected Publications

Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P, Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI. (2019). Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. CA Cancer J Clin; Sep;69(5):402-429. PMID: 31283845

Bononi A*, Yang H*, Giorgi C*, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, Carbone M. (2017). Germline BAP1mutations induce a Warburg effect. Cell Death Differ, June 30. doi: 10.1038/cdd,2017.95. Epub ahead of print.(* These authors contributed equally to this work).

Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, MNapolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H*, Pinton P*, Carbone M*. (2017). BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature, 546:549-553. doi: 10.1038/nature22798. (* co-corresponding authors).

Szymiczek A, Carbone M, Pastorino S, Napolitano A, Tanji M, Minaai M, Pagano I, Mason JM, Pass HI, Bray MR, Mak TW and Yang H. (2017). Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma. Oncogene. 36(49): 6501-6507. PMID: 28759042.

Carbone M, Flores EG, Emi M, Johnson TA, Tsunoda T, Behner D, Hoffman H, Hesdorffer M, Nasu M, Napolitano A, Powers A, Minaai M, Baumann F, Bryant-Greenwood P, Lauk O, Kirschner MB, Weder W, Opitz I, Pass HI, Gaudino G, Pastorino S, Yang H. (2015). Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s. PLoS Gene, Dec 18;11(12):e1005633. PMID: 26683624.

Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings CJ, De Marchis F, Flores EG, Larson D, Pagano I, Tanji M, Powers A, Kanodia S, Gaudino G, Pastorino S, Pass HI, Pinton P, Bianchi ME, Carbone M. (2015). Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression. Cell Death Dis, Jun 11;6:e1786. PMID: 26068794.

Publication list via PubMed

Active Grants

Carbone, Contact PI; Yang, Co-PI
NIH/NCI
1R01CA237235-01
Mechanisms of BAP1 activity in human cancer development
12/13/2019-11/30/24

Carbone, Contact PI; Grzymski, Yang (Partner-PIs)
NIH/NIEHS
1R01ES030948-01
Influence of germline mutations on susceptibility to environmental carcinogens
08/15/2019-06/30/22

H. Yang, Co-PI; Pass, Contact PI
NCI
1 U01CA214195-01
"The EDRN Mesothelioma Biomarker Discovery Laboratory"
09/01/16 - 08/31/21

Yang Initiating PI; Carbone, Mak, Pass, Fert-Bober, Partner PIs
DoD
W81XWH-16-1-0440
DoD Peer Reviewed Cancer Research Program Translational Team Science Award
HMGB1 and Its Isoforms As Biomarkers For Mineral Fiber Exposure and MM Detection
09/01/16-08/31/20 (NCE)

Carbone PI; Yang, Co-I
NCI
1R01CA198138-01
Germline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early Detection
07/01/15-06/30/20